克罗米酚对成年人低促性腺素性功能减退症有效

纽约（路透社健康版）1翌年四日华盛顿邮报：据发表文章在12翌年出版的《生孩子与不孕》华尔街日报的一项调查结果指出克罗米酚对部分较低促性腺芝性功能减退的未孩童病患者薄弱。来自曼彻斯特阿拉巴马大学的该调查结果的第一译者Scott J. Whitten指导教授在给予路透新闻社采访时说：“原发性或能避免HH病患者在给予侵害性更大和更为较贵的治疗（例如注射促性腺激芝类）前顺利完成4个翌年的克罗米酚试验性治疗是薄弱的。”Whitten指导教授和同事分析了克罗米酚对10名HH未孩童病患者（HH是引致未孩童不孕的鲜见因芝）究竟有效。调查结果称克罗米酚治疗1年后，4名卡尔曼(氏)综合征病患者当中只有一名病患者的体外电导率增加而全垂体功能减退症病患者的体外缺乏症状均没有得到提升。相反，该调查结果指出3名孩童发病的原发性HH未孩童病患者经过3个翌年克罗米酚的治疗体外电导率有了明显增加。目前为止该组病患者已有两名直至了生孩子能力。Whitten指导教授说：“除非对克罗米酚治疗没有重排，我们不会因为副作用终止对病患者运用于该药物。”之后译者概括说：“因为条件有限，对HH病患者促性腺激芝类药物和克罗米酚的随机分析难以顺利完成，然而利用多系列的符合选择规范对病患者顺利完成分级可能会尽力进一步检验克罗米酚直至未孩童较低生孩子能力的有效性。 Male Hypogonadotropic Hypogonadism May Respond to Clomiphene CitrateBy Will Boggs, MDNEW YORK (Reuters Health) Jan 04 - Some men with hypogonadotropic hypogonadism (HH) benefit from treatment with clomiphene citrate, according to a report in the December issue of Fertility and Sterility.Patients with idiopathic or acquired HH "may benefit from a 4-month trial (of clomiphene citrate) before proceeding with more invasive and expensive therapies, such as injectable gonadotropins," lead author Dr. Scott J. Whitten, from University of Alabama at Birmingham, told Reuters Health.Dr. Whitten and colleagues investigated whether 10 men with HH, a rare cause of male infertility, might respond to treatment with clomiphene citrate.Only one of four patients with Kallmann's syndrome experienced an improvement in sperm concentration after 1 year of therapy with clomiphene citrate, the authors report, and no patient with panhypopituitarism experienced a reversal of azoospermia with clomiphene citrate treatment.In contrast, all three men with -onset idiopathic HH experienced significant increases in sperm concentrations and testosterone levels after 3 months of therapy with clomiphene citrate, the report indicates. Two pregnancies he been achieved in this subgroup so far."We did not he any of our patients discontinue the clomiphene because of side effects, only if there was lack of response," Dr. Whitten said."Because this is such a rare condition, additional randomized studies comparing gonadotropins with clomiphene in this subtype of HH patients would be difficult to perform," the authors conclude. "However, larger series using strict inclusion criteria for stratifying patients may be helpful to further examine the success of clomiphene treatment in restoration of this form of male subfertility."Fertil Steril 2006;86:1664-1668.

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主编： 张靖